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by Selena Larson @selenalarson June 19, 2017: 11:32 PM ET
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North Korea's cyber wars

Personal information of almost 200 million registered U.S. voters was accidentally exposed online due to an improperly configured security setting, security firm UpGuard revealed on Monday.

The leaked information , compiled by Republican data firm Deep Root Analytics and two other Republican contractors, included names, birth dates, addresses, voter registration details and social media posts.

UpGuard cyber risk analyst Chris Vickery discovered the open database of 198 million voters on June 12, and it was secured on June 14. Putting that number into context, Politico reported Calvin Klein Glorianne Sling Back Block Heel Dress Pumps arXnJFP0
.

About 1.1 terabytes of data was available to download and not password protected.

"This the DNA of voter analysis," Vickery told CNNTech. "This is exactly what they use to determine how someone is likely to vote on a specific issue."

Deep Root said in a statement the data was exposed on June 1 when the firm updated security settings. The firm said it "builds voter models to help enhance advertiser understanding of TV viewership."

The Republican National Committee said in a statement that it has stopped further work with Deep Root "pending the conclusion of their investigation into security procedures."

"While Deep Root has confirmed the information accessed did not contain any proprietary RNC information, the RNC takes the security of voter information very seriously and we require vendors to do the same," it said.

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This article discusses the principles and values of Conservative Judaism and provides statistics and an overview of the history of the movement.

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...the point of this form of Judaism is to make Judaism live in our own lives and in those of our descendants by balancing and mixing the traditional with the modern.

Conservative Judaism is a form of traditional Judaism that falls halfway between Orthodox Judaism and Reform Judaism. It is sometimes described as traditional Judaism without fundamentalism.

Masorti is traditional Judaism practised in a spirit of open-minded enquiry and tolerance.

Despite its middle-of-the-road position, Conservative Judaism is independent of both Orthodoxy and Reform.

Conservative Judaism, while rejecting both what it sees as the fundamentalism of Orthodoxy and the untraditionalism of Reform, adopts a positive religious position of its own in which Jewish piety can be fully at home in minds open to the best of modern thought.

Conservative Judaism is also known (particularly in Israel and the UK) by the Hebrew word 'Masorti', which means 'traditional'.

The Conservative Jewish community in Britain is coordinated by the Assembly of Masorti Synagogues.

Our goal is to become the denomination of choice for the traditional, non-fundamentalist, British Jew

Conservative Judaism in the USA is organised by the United Synagogue of Conservative Judaism. The movement grew strongly in the 1950s and 1960s to become the most popular form of American Judaism, but more recently affiliations have fallen, and it now comes second to Reform Judaism.

The international organisation is Masorti Olami, the World Council of Conservative/Masorti Synagogues.

The Conservative/Masorti movement practices traditional Judaism, but interprets Jewish teaching in the light of contemporary knowledge and scholarship.

Conservative Judaism allows gradual change in law and practice, but only if the change is in harmony with Jewish tradition.

The wish to embrace both tradition and change may seem admirable, but it is a very difficult one to live out since it's hard to develop a clear theology that can provide a consistent path between the two standpoints. The tendency has been to tackle each issue individually, rather than to embark on a global rethink.

Ismar Schorsch has set down a Sacred Cluster of core values of Conservative Judaism (the commentary is editorial, not part of the original):

View larger version:
FIG 10

Effects of SLFN5 knockdown on collagen contraction. (A) Control shRNA-GFP (upper panels) and SLFN5 shRNA-GFP (lower panels) cells (1 × 10) were plated in a 3D collagen contraction assay. The GM6001 (GM) inhibitor was added to the medium at a 10 μM final concentration, as indicated (right panels). Collagen contraction was assessed after 4 days of culture. The figure shows three independent experiments (I, II, and III). (B) The surface area of the inner gel plugs from panel A was quantified using ImageJ. The relative changes in the surface area were recorded as the percentage of the original surface area. Shown here is the percentage of collagen contraction ± standard errors of results from three independent experiments. (C) 786-0 control shRNA-GFP cells were transiently transfected with control siRNA, MMP-1 siRNA, or MMP-13 siRNA. At 48 h after transfection, gene expression of MMP-1 and MMP-13 was analyzed by real-time RT-PCR using specific primers and GAPDH as an internal control. Data are expressed as fold changes over the control and represent the mean ± standard error of results from three experiments. (D) Control shRNA-GFP (upper panels) and SLFN5 shRNA-GFP (lower panels) cells were transiently transfected with control siRNA, MMP-1 siRNA, or MMP-13 siRNA. At 48 h after transfection, the cells were plated in a 3D collagen contraction assay. Collagen contraction was assessed after 4 days of culture. The figure is representative of three independent experiments. (E) The surface area of the inner gel plugs from panel D was quantified using ImageJ. The relative changes in the surface area were recorded as the percentage of the original surface area. Shown here is the percentage of collagen contraction ± the standard error of results from three independent experiments.

Since MMPs also mediate cell migration and invasion, we next examined the effects of SLFN5 knockdown on cell motility by live-cell imaging. Cells transfected with SLFN5 siRNA demonstrated increased cell motility ( Frye Kristen Harness Over The Knee aCMKqTl
; see also Movies S1 and S2 in the supplemental material). SLFN5 knockdown also increased migration in a transwell migration assay ( Converse Chuck Taylor All Star Street Letterman Jacket Mid S1K7Dw
and C ). In addition, SLFN5 knockdown increased invasion of 786-0 cells through Matrigel-coated transwell membranes ( Fig. 11D and E ). Taken together, these results provide strong evidence for a key negative regulatory role for SLFN5 in RCC tumor progression.

View larger version:
FIG 11

SLFN5 inhibits malignant cell migration. (A) 786-0 cells were transiently transfected with control siRNA or SLFN5 siRNA, as indicated; at 48 h after transfection, cells were transferred to a Nikon Biostation incubator wide-field microscope and time-lapse images were acquired at 10-min intervals for 12 h. Data were analyzed using the Nikon Elements software. Data represent the means ± standard errors of results from 27 migratory events detected by the Nikon Elements software. (B) 786-0 cells were transiently transfected with control siRNA or SLFN5 siRNA, as indicated. At 48 h after transfection cells, were plated in BD BioCoat cell culture inserts for 3 h and then cells were stained. Representative images of migrating cells (×5) after 3 h of incubation are shown. (C) The migrated cells were counted, and relative migration is expressed as the fold increase over control ± standard error of results from three independent experiments. Paired two-tailed test analysis showed a value of 0.0198 (*). (D) 786-0 cells were transiently transfected with control siRNA or SLFN5 siRNA. At 48 h after transfection, the cells were plated in a Corning BioCoat Matrigel invasion chamber, and invasion of the cells was assessed in 6 h. Representative images of invading cells (×5) after 6 h of incubation are shown. (E) The invading cells were counted, and relative invasion is expressed as the fold increase over controls ± standard errors of results from four independent experiments. Paired two-tailed test analysis showed a value of 0.02933 (*).

Since our results using renal cell carcinoma cell lines provided evidence for a potential important functional role for SLFN5 in RCC progression, we next sought to determine the expression of SLFN5 in RCC samples and whether its expression was linked to overall survival. We analyzed a recently obtained RNA-seq data set of 470 RCC samples and compared the data to 68 nontumor control kidney samples ( 28 , 31 ). Although SLFN5 was significantly overexpressed in RCC samples ( t test, P value = 2 × 10 −6 ) ( Sigerson Morrison Jana Slingback Sandal SK3TcX
), higher expression of SLFN5 was significantly associated with a better overall survival in RCC samples (log rank, P value = 0.003) ( Reebok Reebok Club MEMT 9gIfIdD
). In addition, when the prognostic effects of MMP-1 or MMP-13 in RCC were evaluated, we found that high MMP-13 expression correlated significantly with adverse overall survival ( Fig. 12C ), while MMP-1 independently did not show any significant correlation with survival ( Spring Step Delano Tall Boots Z4tDETbt2K
).

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